Adrenal Insufficiency or Fatigue

Dr. Weyrich's Naturopathic Functional Medicine Notebook

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Neuro Research [Hinz2015] reports that Adrenal Insufficiency or Fatigue can be benefited by balancing neurotransmitter and sulfur-containing amino acid levels in the body, particularly serotonin, dopamine, and cysteine, through targeted nutrition guided by lab testing. Dr. Weyrich has been trained in the Neuro-Research protocols and offers these nutritional protocols as a complement to other therapies.

Note that nutritional supplements and testing are not covered by most insurance policies, but may be eligible for payment out of Health Care Savings Accounts.


Symptoms of adrenal insufficiency include:

Differential Diagnosis


Mild adrenal deficiency can be safely treated with low-dose cortisol, e.g. 4 to 30 mg/day in divided doses [Starr2005, pg 185]. Supplementation with thyroid hormone can further reduce side effects of cortisol supplementation [Starr2005, pg 185].

Dr. Starr suggests that patients being treated with corticosteroids should have a home blood-pressure machine, and take BP before a dose of corticosteroids and 1.5 to 2 hours after dose. If BP and heart rate normalize dose is correct; if these parameters get worse then the dose is too high [Starr2005, pg 190].


Unless specifically noted above, references used in the construction of this web page include the following:

[FDM] Lecture notes from Functional Medicine University.

[SCNM] Lecture notes from Southwest College of Naturopathic Medicine.

[UT] Lecture notes from the University of Tennessee graduate programs in Chemistry and Biochemistry.

[Brownstein2008] Brownstein D. Iodine: Why You Need It, Why You Can't Live Without It, Third Edition. Medical Alternatives Press (2008). See also [Cited by Starr2005].

[Hinz2015] Martin C Hinz, MD. Managing Relative Nutritional Deficiencies associated with the centrally acting monoamines (Serotonin, Dopamine, Norepinephrine and/or Epinephrine. Neuro Research Clinics. AMA Category 1 Continuing Medical Education seminar. September 26, 2015, Phoenix, AZ.

[Starr2005] Mark Starr. Hypothyroidism Type 2: The Epidemic. Columbia, MO: Mark Starr Trust (2005).

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