Mania is a mental illness characterized by an excessively elated mental state and hyperactivity that is out of proportion to reality. In this state, common sense inhibitions may be lost and excessive risk-taking behavior may be manifest. Depending on severity of symptoms, mania may be classified as psychotic or nonpsychotic (hypomania).

A useful online overview can be found at wikipedia; the definitive printed reference is the DSM-5 manual, which is not freely available online.

It is outside Dr. Weyrich's scope to prescribe anti-psychotic drugs to treat mania, but Dr. Weyrich can provide adjunctive therapies that may be very beneficial, and allow the doctors prescribing anti-psycotics to minimize the doses (and side effects).

Mania may be benefited by balancing neurotransmitter and sulfur-containing amino acid levels in the body, particularly serotonin, dopamine, and cysteine, through targeted nutrition guided by lab testing [Hinz2015] . Dr. Weyrich has been trained in the Neuro-Research protocols and offers these nutritional protocols as a complement to other therapies.

In addition, Neuro-feedback may also be useful for treating persons prone to mania. Neuro-feedback is a form of biofeedback based on using Quantitative Electro-encephalography (QEEG) to obtain a "brain-map" of the patient, which is then compared to a database of "normal" brain-maps of age-and-gender-matched individuals. Neuro-feedback techniques are then used to teach the patient how to "restructure" the activity of his/her own brain to match the corresponding normative database brain-maps. Dr. Weyrich has been certified in Neuro-feedback since 2008, and recently completed an additional residency training program at ADD Clinic of Scottsdale, AZ.

Note that brain-mapping, neuro-feedback, nutritional supplements and testing are not covered by most insurance policies, but may be eligible for payment out of Health Care Savings Accounts.

However, the greatest impediment to treatment of mania is that the patient is often uncooperative and unwilling to be treated. Psychotic mania is often treated either as an in-patient or as a court-ordered supervised out-patient. Under these circumatances, balancing neurotransmitters and neuro-feedback techniques may be difficult to implement.


The cause of mania is poorly understood, but some practioners have noted an association between hypothyroidism, adrenal insufficiency, and mania; treatment of these disorders appears to also benefit mania [Zondek1944b; Starr2005, pg 124].

Differential Diagnosis

ICD-10 Codes


Unless specifically noted above, references used in the construction of this web page include the following:

[FDM] Lecture notes from Functional Medicine University.

[SCNM] Lecture notes from Southwest College of Naturopathic Medicine.

[UT] Lecture notes from the University of Tennessee graduate programs in Chemistry and Biochemistry.

[DSM-5] American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th Edition. ISBN:978-0890425558 (2013).

[Hinz2015] Martin C Hinz, MD. Managing Relative Nutritional Deficiencies associated with the centrally acting monoamines (Serotonin, Dopamine, Norepinephrine and/or Epinephrine. Neuro Research Clinics. AMA Category 1 Continuing Medical Education seminar. September 26, 2015, Phoenix, AZ.

[Starr2005] Mark Starr. Hypothyroidism Type 2: The Epidemic. Columbia, MO: Mark Starr Trust (2005).

[Stuart2006] J.J. Stuart & S.M. Pacholok. Could it be B12? An Epidemic of Misdiagnoses. Sanger, CA: Quill Driver Books/Word Dancer Press (2006).

[Zondek1944b] H. Zondek & G. Wolfsohn. Myxoedema and Psychosis. Lancet 2:438-439 (1944). [Cited by Starr2005].