Test Overview

Screening test for gut dysbiosis.

Test Indications

Sample Collection

Your doctor or lab may have different instructions that supersede the above.


Dysbiotic anaerobic bacteria in the gut convert the amino acid tryptophan into indole. The indole is absorbed from the gut and processed in the liver via phase 1 into 3-hydroxy indole, and then via the phase 2 glucuronidation pathway into indole glucuronidate, which is excreted by the kidneys.

Elevated levels of indican suggest:


Unless specifically noted above, references used in the construction of this web page include the following:

[FDM] Lecture notes from Functional Medicine University.

[SCNM] Lecture notes from Southwest College of Naturopathic Medicine.

[UT] Lecture notes from the University of Tennessee graduate programs in Chemistry and Biochemistry.