Test Overview of Urinary Indican (3-Hydroxy Indole)Screening test for gut dysbiosis.
Test Indications of Urinary Indican (3-Hydroxy Indole)
- New patients.
Sample Collection for Urinary Indican (3-Hydroxy Indole)
- Requires random urine sample.
Your doctor or lab may have different instructions that supersede the above.
Theory of Urinary Indican (3-Hydroxy Indole)Dysbiotic anaerobic bacteria in the gut convert the amino acid tryptophan into indole. The indole is absorbed from the gut and processed in the liver via phase 1 into 3-hydroxy indole, and then via the phase 2 glucuronidation pathway into indole glucuronidate, which is excreted by the kidneys.
Elevated levels of indican suggest:
- Putrification of maldigested or malabsorbed protein, possibly due to hypochlorhydria.
- Bowel toxemia due to overgrowth of anaerobic bacteria (dysbiosis), possibly leading to candidiasis and leaky gut syndrome.
- High protein intake or tryptophan supplementation.
References regarding Urinary Indican (3-Hydroxy Indole)
Unless specifically noted above, references used in the construction of this web page include the following:
[FDM] Lecture notes from Functional Medicine University.
[SCNM] Lecture notes from Southwest College of Naturopathic Medicine.
[UT] Lecture notes from the University of Tennessee graduate programs in Chemistry, Microbiology, and Biochemistry.