Test Overview

Measurement of amino acids and derivatives in the urine can help evaluate nutritional status, the presence of inborn errors of metabolism, urea cycle defects, digestive and GI status, detoxification status, and neurological indicators.

Test Indications

Sample Collection

  1. Your doctor will provide you with the sample collection kit that includes sample container, gel-pack, and shipping materials.
  2. Avoid amino acid supplements and unusually large protein meals for 24 hours before collecting urine.
  3. Place gel-pack in the freezer the night before sample collection.
  4. Collect at least 15 mL of FIRST MORNING URINE, before eating or drinking (or use special pediatric collection bag overnight if patient is not potty trained).
  5. Refrigerate sample (do not freeze) until ready to send to lab.
  6. The sample must be sent via overnight FedEx directly to the lab on a Monday through Thursday using the prepaid mailer provided.
  7. Detailed instructions are in the sample collection kit.

Your doctor or lab may have different instructions that supersede the above.

CPT CODES

CPT-CodeDescriptionComments
82139Amino Acids, 6 or more 
82140Ammonia 

Labs Performing Test

Name of LabLab CodeEstimated CostProcessing TimeComments
Great Plains  $2192-3 weeksCash discount and some insurance

Costs cited are subject to change and may be reduced by insurance or cash discounts and increased by sample collection fees.

Theory

Depressed levels of all or many amino acids in the urine suggests low protein intake, digestion (low HCl or proteases), or absorption, or dysbiosis.

Elevated levels of all or many amino acids in the urine suggests high protein intake, renal tubular defect (genetic defect or toxicity).

Alanine

Alpha-Amino-N-butyric Acid

Alpha-Aminoadipic Acid

Ammonia

Anserine

Arginine

Asparagine

Aspartic Acid

Beta-Alanine

Beta-Aminoisobutyric Acid

Carnosine

Citrulline

Creatinine

Cystathionine

Cysteine

Cystine

Ethanolamine

Gamma-Aminobutyric Acid

Glutamic Acid

Glutamine

Glycine

Histidine

Homocysteine

Hydroxyproline

Isoleucine

Leucine

Lysine

Methionine

Methionine Sulfoxide

1-Methylhistidine

3-Methylhistidine

Ornithine

Phenylalanine

Phosphoethanolamine

Phosphoserine

Proline

Sarcosine

Serine

Taurine

Threonine

Tryptophan

Tyrosine

Urea

Valine


References

Unless specifically noted above, references used in the construction of this web page include the following:

[FDM] Lecture notes from Functional Medicine University.

[SCNM] Lecture notes from Southwest College of Naturopathic Medicine.

[UT] Lecture notes from the University of Tennessee graduate programs in Chemistry and Biochemistry.

[GP] Great Plains Laboratory Physician Training lecture notes and documentation.